T-cells – ZELLKRAFTWERK

Absence of regulatory T cells causes phenotypic and functional switch in murine peritoneal macrophages

Jelena Skuljec and colleagues used FOXP3-deficient scurfy (Sf) mice to investigate the behavior of peritoneal macrophages in terms of the missing crosstalk with Tregs. [...]

Monocyte/macrophage lineage commitment and distribution are affected by the lack of regulatory T cells in scurfy mice

Skuljec J, Cabanski M, Surdziel E, Lachmann N, Brennig S, Pul R, Jirmo AC, Habener A, Visic J, Daluege K, Hennig C, Moritz T, Happle C, Hansen G. Eur J Immunol. 2016. [...]

a-NAC-specific autoreactive CD8+ T cells in atopic dermatitis are of an effector-memory 2 type and secrete IL-4 and IFN-y

In this publication, antigen-specific T-cells were detected and intensively phenotype using the rare-cell detection feature of Chipcytometry and MHC-I specific tetramers on living cells [...]

Allergy prevention starts before conception: maternofetal transfer of tolerance protects against the development of asthma

In this project, chipcytometry was used to analyze in detail the antigen-specific immune response in offspring of mice that had been tolerized to a certain allergen. Surprisingly, it was found [...]

CD3+CD20+ T cells in peripheral blood: Proper flow cytometry is a prerequisite of exact phenotyping

Here, Chipcytometry was used as an supportive technology to demonstrate that flow cytometry data are correct showing that CD20 expressing T-cells exist. Wilk E, Witte T, Marquardt N, Hennig C, [...]