Mouse – ZELLKRAFTWERK

Absence of regulatory T cells causes phenotypic and functional switch in murine peritoneal macrophages

Jelena Skuljec and colleagues used FOXP3-deficient scurfy (Sf) mice to investigate the behavior of peritoneal macrophages in terms of the missing crosstalk with Tregs. [...]

Pulmonary Transplantation of Human iPSC-derived Macrophages Ameliorates Pulmonary Alveolar Proteinosis.

In this first-ever proof-of-concept study for the therapeutic potential of human iPSC-derived cells in a pulmonary disease, Christine Happle and colleagues use Chipcytometry to analyse the [...]

Monocyte/macrophage lineage commitment and distribution are affected by the lack of regulatory T cells in scurfy mice

Skuljec J, Cabanski M, Surdziel E, Lachmann N, Brennig S, Pul R, Jirmo AC, Habener A, Visic J, Daluege K, Hennig C, Moritz T, Happle C, Hansen G. Eur J Immunol. 2016. [...]

Allergy prevention starts before conception: maternofetal transfer of tolerance protects against the development of asthma

In this project, chipcytometry was used to analyze in detail the antigen-specific immune response in offspring of mice that had been tolerized to a certain allergen. Surprisingly, it was found [...]

Lung function and inflammation during murine Pseudomonas aeruginosa airway infection

Woelbeling F, Munder A, Kerber-Momot T, Neumann D, Hennig C, Hansen G, Tuemmler B, Baumann U. Immunobiology. 2011. https://www.ncbi.nlm.nih.gov/pubmed/21497410