Absence of regulatory T cells causes phenotypic and functional switch in murine peritoneal macrophages
Jelena Skuljec and colleagues used FOXP3-deficient scurfy (Sf) mice to investigate the behavior of peritoneal macrophages in terms of the missing crosstalk with Tregs. [...]
Monocyte/macrophage lineage commitment and distribution are affected by the lack of regulatory T cells in scurfy mice
Skuljec J, Cabanski M, Surdziel E, Lachmann N, Brennig S, Pul R, Jirmo AC, Habener A, Visic J, Daluege K, Hennig C, Moritz T, Happle C, Hansen G. Eur J Immunol. 2016. [...]
Der p1 and Der p2-specific T cells display a Th2, Th17, and Th2/Th17 phenotype in atopic dermatitis
Roesner LM, Heratizadeh A,Begemann G,Kienlin P,Hradetzky S,Niebuhr M,Eiz-Vesper B,Hennig C,Hansen G,Baron-Bodo V,Moingeon P,Werfel T. Journal of Investigative Dermatology. 2015. [...]
Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis
In this excelent study, both single cell and tissuecytometry options of Chipcytometry were applied to implement a high-content in-depth analysis of transplanted cells in an humanized mouse model. [...]
a-NAC-specific autoreactive CD8+ T cells in atopic dermatitis are of an effector-memory 2 type and secrete IL-4 and IFN-y
In this publication, antigen-specific T-cells were detected and intensively phenotype using the rare-cell detection feature of Chipcytometry and MHC-I specific tetramers on living cells [...]
Allergy prevention starts before conception: maternofetal transfer of tolerance protects against the development of asthma
In this project, chipcytometry was used to analyze in detail the antigen-specific immune response in offspring of mice that had been tolerized to a certain allergen. Surprisingly, it was found [...]
Successful treatment of autoimmune and lymphoproliferative complications of patients with intrinsic B-cell immunodeficiencies with Rituximab
Hennig C, Baumann U, Ilginus C, Horneff G, Foell J, Hansen G. Br J Haematol. 2010. https://www.ncbi.nlm.nih.gov/pubmed/19922533
CD3+CD20+ T cells in peripheral blood: Proper flow cytometry is a prerequisite of exact phenotyping
Here, Chipcytometry was used as an supportive technology to demonstrate that flow cytometry data are correct showing that CD20 expressing T-cells exist. Wilk E, Witte T, Marquardt N, Hennig C, [...]
Lung function and inflammation during murine Pseudomonas aeruginosa airway infection
Woelbeling F, Munder A, Kerber-Momot T, Neumann D, Hennig C, Hansen G, Tuemmler B, Baumann U. Immunobiology. 2011. https://www.ncbi.nlm.nih.gov/pubmed/21497410