PRECLINICAL SERVICES - CLINICAL SERVICES PRECISION MEDICINE

PRECLINICAL SERVICES

 

Ultra-Deep Phenotyping of Immune Cells

High parameter single-cell analysis by ChipCytometry has proven to be a powerful tool to investigate target selection and validation and to elucidate drug mechanisms of action. Conventional ChipCytomery applications include:

  • Deep Cell Immune Cell Phenotyping (>40 parameters)
  • Cell Cycle Analysis
  • Mode of Action, Target Engagement
  • Cell Signaling
  • Intracellular Cytokine Secretion
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Roesner et al. Journal of Investigative Dermatology 2015: Der p1 and Der p2-specific T cells display a Th2, Th17, and Th2/Th17 phenotype in atopic dermatitis.

CLINICAL SERVICES

 

Long-Term Sample Storage and Reinterrogation

The use of conventional flow cytometry in a clinical setting is often limited in terms of sample stability, inter-laboratory variations, inter-operator variability, and instrument drift. ChipCytometry enables sample stability for analysis and reinterrogation for an approximately 24-month period.

ChipCytometry is the only cytometric technology enabling global clinical trial support using a single instrument. The validated automated gating algorithms eliminate unwanted noise from datasets.

Using ZellSafe™ chips, clinical trial samples are biobanked after analysis, enabling the reinterrogation of patient samples after study completion.

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PRECISION MEDICINE

 

Companion Diagnostic Development

Disruptive ChipCytometry helps in identifying predictive biomarkers, developing and deploying diagnostic tests, and engaging the most suitable patient cohorts to demonstrate the safety and efficacy of your therapeutic product(s).

Through our experience, we will help you to avoid obstacles and optimize your path to developing new personalized medicine and companion diagnostics, accelerating the way to decision biomarkers supporting your drug development program.

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SOP – STANDARD OPERATING PROCEDURES

Preparation and Biobanking of PBMCs for ChipCytometry using CPT™ tubes for Zellsafe Rare Chips

Isolation of PBMCs from whole blood for biobanking and further analysis by ChipCytometry using CPT™ tubes, version for Zellsafe Rare Chips.

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Preparation of PBMCs for ChipCytometry using CPT™ tubes

Isolation of PBMCs from whole blood for biobanking and further analysis by ChipCytometry using CPT™ tubes.

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Preparation and fixation of tissue cryosections on ZellSafe_T chips

Preparation and fixation of tissue cryosections on ZellSafe_T chips.

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Preparation of leukocytes from lung cell culture cells

Preparation of leukocytes after lung cell culture from dissociated lung tissues for ChipCytometry.

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Preparation and fixation of short-term cultured cells on ZellSafe_C chips

Preparation and fixation of primary cells cultured for up to 24 h on ZellSafe_C chips.

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Preparation and fixation of human BAL cells on ZellSafe_C chips

Preparation and fixation of cellular components contained in bronchoalveolar lavage fluid on ZellSafe_C chips.

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Preparation of Leukocytes from CSF for ChipCytometry

Isolation of leukocytes from cerebrospinal fluid (CSF) for biobanking and analysis by ChipCytometry.

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Preparation of Leukocytes by Erythrocyte lysis for ChipCytometry

Isolation of leukocytes from whole blood by erythrocyte lysis for fixation on ZellSafe chips.

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Preparation of PBMCs for ChipCytometry using Ficoll

Isolation of PBMCs from whole blood for biobanking and further analysis by ChipCytometry.

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