PRECLINICAL SERVICES - CLINICAL SERVICES PRECISION MEDICINE

PRECLINICAL SERVICES

 

Ultra-Deep Phenotyping of Immune Cells

High parameter single cell analysis by Chipcytometry has proven to be a powerful tool to investigate target selection and validation and to elucidate drug mechanism of action. Typical Chipcytomery applications are:

  • Deep Cell Immune Cell Phenotyping (>40 parameters)
  • Cell Cycle Analysis
  • Mode of Action, Target Engagement
  • Cell Signaling
  • Intracellular Cytokine Secretion
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Roesner et al. Journal of Investigative Dermatology 2015: Der p1 and Der p2-specific T cells display a Th2, Th17, and Th2/Th17 phenotype in atopic dermatitis.

CLINICAL SERVICES

 

Long-Term Sample Storage and Re-Interrogation

In a clinical trial setting conventional Flow Cytometry is often limited in terms of sample stability, inter-lab variations, inter-operator variability and instrument drift. Chipcytometry enables sample stability for analysis and re-interrogation for about 24 months.

Chipcytometry is the only cytometry technology enabling global clinical trial support using a single instrument and validated automated gating algorithms eliminates unwanted noise from your data sets.

Using ZellSafe™ chips, clinical trial samples are biobanked after analysis, enabling re-interrogation of patient samples after the study is completed.

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PRECISION MEDICINE

 

Companion Diagnostic Development

Disruptive Chipcytometry helps you identify predictive biomarkers, develop and deploy diagnostic tests, and engage the most appropriate patient populations to demonstrate the safety and efficacy of your therapeutic products.

Our experience will help you to avoid obstacles and optimize your path to developing new personalized medicines and companion diagnostics and accelerate the path to decision biomarkers supporting your drug development programs.

precision_medicine

SOP – STANDARD OPERATING PROCEDURES

Preparation of PBMC for Chipcytometry using CPT™ tubes

This SOP describes how to isolate PBMCs from whole blood for biobanking and later analysis by Chipcytometry using CPT™ tubes.

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Preparation and fixation of tissue cryosections on ZellSafe_T chips

This SOP describes how to prepare and fix tissue cryosections on ZellSafe_T chips.

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Preparation of leukocytes from lung cell culture cells

This SOP describes how to prepare leukocytes after lung cell culture from dissociated lung tissues for
chipcytometry.

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Preparation and fixation of short term cultured cells on ZellSafe_C chips

This SOP describes how to prepare and fix primary cells that have been cultured for up tp 24h on ZellSafe_C
chips.

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Preparation and fixation of human BAL cells on ZellSafe_C chips

This SOP describes how to prepare and fix cells from broncho-alveolar lavage from patients on ZellSafe_C chips.

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Preparation of Leukocytes from CSF for Chipcytometry

This SOP describes how to isolate leukocytes from CSF for biobanking and analysis by Chipcytometry.

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Preparation of Leukocytes by Erythrocyte lysis for Chipcytometry

This SOP describes how to isolate leukocytes from whole blood by erythrocyte lysis for fixation on ZellSafe chips.

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Preparation of PBMC for Chipcytometry using Ficoll

This SOP describes how to isolate PBMCs from whole blood for biobanking and later analysis by Chipcytometry.

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