PUBLICATIONS DESCRIBING ASPECTS OF THE TECHNOLOGY
PUBLICATIONS USING CHIPCYTOMETRY
A preliminary study for the assessment of PD-L1 and PD-L2 on circulating tumor cells by microfluidic-based chipcytometry
In this study, David Skibinski and colleagues from Merck Singapore developed a method to use Chipcytometry for detection and phenotyping of circulating tumor cells in patient blood.
Gain-of-function STAT1 mutations are associated with intracranial aneurysms
Dadak M, Jacobs R, Skuljec J, Jirmo AC, Yildiz Ö, Donnerstag F, Baerlecken NT, Schmidt RE, Lanfermann H, Skripuletz T, Schwenkenbecher P, Kleinschnitz C, Tumani H, Stangel M, Pul R. Clin Immunol. 2017.
Monocyte/macrophage lineage commitment and distribution are affected by the lack of regulatory T cells in scurfy mice
Skuljec J, Cabanski M, Surdziel E, Lachmann N, Brennig S, Pul R, Jirmo AC, Habener A, Visic J, Daluege K, Hennig C, Moritz T, Happle C, Hansen G. Eur J Immunol. 2016.
a-NAC-specific autoreactive CD8+ T cells in atopic dermatitis are of an effector-memory 2 type and secrete IL-4 and IFN-y
In this publication, antigen-specific T-cells were detected and intensively phenotype using the rare-cell detection feature of Chipcytometry and MHC-I specific tetramers on living cells immobilized inside the XXL-chips.
Roesner LM, Heratizadeh A, Wieschowski S, Mittermann I, Valenta R, Eiz-Vesper B, Hennig C, Hansen G, Falk CS, Werfel T. Journal of Immunology. 2016.
Der p1 and Der p2-specific T cells display a Th2, Th17, and Th2/Th17 phenotype in atopic dermatitis
Roesner LM, Heratizadeh A,Begemann G,Kienlin P,Hradetzky S,Niebuhr M,Eiz-Vesper B,Hennig C,Hansen G,Baron-Bodo V,Moingeon P,Werfel T. Journal of Investigative Dermatology. 2015.
Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis
In this excelent study, both single cell and tissuecytometry options of Chipcytometry were applied to implement a high-content in-depth analysis of transplanted cells in an humanized mouse model.
Happle C, Lachmann N, Skuljec J, Wetzke M, Ackermann M, Brennig S, Mucci A, Chari AJ, Groos S, Mirenska A, Hennig C, Rodt T, Bankstahl JP, Schwerk N, Moritz T, Hansen G. Science Translational Medicine. 2014.
Successful treatment of autoimmune and lymphoproliferative complications of patients with intrinsic B-cell immunodeficiencies with Rituximab
Hennig C, Baumann U, Ilginus C, Horneff G, Foell J, Hansen G. Br J Haematol. 2010.
Identification and quantification of basophils in the airways of asthmatics following segmental allergen challenge
Dijkstra D, Hennig C, Hansen G, Biller H, Krug N, Hohlfeld JM. Cytometry A. 2014.
Allergy prevention starts before conception: maternofetal transfer of tolerance protects against the development of asthma
In this project, chipcytometry was used to analyze in detail the antigen-specific immune response in offspring of mice that had been tolerized to a certain allergen. Surprisingly, it was found that Interferon-gamma producing T-cells are induced in these offspring due to diaplacentar immunecomplex-transfer.
Polte T, Hennig C, Hansen G.J Allergy Clin Immunol. 2008.
CD3+CD20+ T cells in peripheral blood: Proper flow cytometry is a prerequisite of exact phenotyping
Here, Chipcytometry was used as an supportive technology to demonstrate that flow cytometry data are correct showing that CD20 expressing T-cells exist.
Wilk E, Witte T, Marquardt N, Hennig C, Hansen G, Schmidt RE, Jacobs R. Arthritis Rheum. 2010.
Lung function and inflammation during murine Pseudomonas aeruginosa airway infection
Woelbeling F, Munder A, Kerber-Momot T, Neumann D, Hennig C, Hansen G, Tuemmler B, Baumann U. Immunobiology. 2011.